Efficacy of erythropoietin combined with tranexamic acid in reducing perioperative blood loss and blood transfusion rate in elderly patients with femoral intertrochanteric fractures

Purpose: To investigate the efficacy of exogenous recombined human erythropoietin (rhEPO), combined with tranexamic acid (TXA) and administered by different routes, in treatment elderly patients femoral intertrochanteric fractures.Methods: 252 Suzhou Xiangcheng People's Hospital were randomly divided into groups (A, B C), 84 each group. All given rhEPO iron sucrose, followed TXA which was via topical injection at fracture site Group A, intravenous infusion B, C. The perioperative actual total blood loss, occult hematocrit (HCT), platelet count (PLT), hemoglobin (Hb), activated partial thromboplastin time (APTT) assessed. Also evaluated prothrombin (PT), fibrinogen (FIB), transfusion rate incidence deep venous thrombosis (DVT) lower limbs. results then compared among three groups.Results: Perioperative loss as well lowest C, A. differences statistically significant (p < 0.05). HCT Hb levels highest A 0.05).Conclusion: Multi-modal administration drugs (rhEPO TXA) is effective treating fractures. strategy efficiently reduces rate, also improves relevant biochemical indicators.